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As used herein, the term homomer, refers to a multimer containing only polypeptides corresponding to the amino acid sequence of SEQ ID NO:2 or encoded by the cDNA contained in a deposited clone (including fragments, variants, splice variants, and fusion proteins, corresponding to these polypeptides as described herein)

It is generally contraindicated, especially in the third trimester, as it can cause premature closure of the ductus arteriosus in the fetus, a vital blood vessel